The Political Declaration on Tuberculosis is a turning point in generating the necessary political awareness and financial commitments to end TB. With TB being the number one killer of people living with HIV, the two diseases are closely linked. This guide calls on the TB and HIV communities to join forces for a collaborative response. In order to see real success, governments must commit the resources and policies necessary to drive implementation in their countries at national, regional, and local levels to reach the targets laid out in the Political Declaration. This guide presents a breakdown of the Political Declaration for a Canadian audience, which includes those working to end TB within Canada and around the world. This document is the next step in our fight against TB. It is intended to be used by community members, practitioners, civil servants, civil society, and others as a guide for Canada to push for accountability in the implementation of the Political Declaration.